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全體研究組長(zhǎng)

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張國(guó)慶

博士

生物醫(yī)學(xué)大數(shù)據(jù)中心執(zhí)行主任

郵箱: gqzhang@sinh.ac.cn

電話: +86-21-54920465

所屬部門: 中國(guó)科學(xué)院計(jì)算生物學(xué)重點(diǎn)實(shí)驗(yàn)室

個(gè)人簡(jiǎn)歷

　　2017-至???今：中國(guó)科學(xué)院上海營(yíng)養(yǎng)與健康研究所生物醫(yī)學(xué)大數(shù)據(jù)中心執(zhí)行主任，平臺(tái)課題組長(zhǎng)
　　2016-2017年：中國(guó)科學(xué)院上海生命科學(xué)研究院?生物醫(yī)學(xué)大數(shù)據(jù)中心副主任，平臺(tái)課題組長(zhǎng)
　　2007-2016年：上海生物信息技術(shù)研究中心生命科學(xué)數(shù)據(jù)中心部門主管
　　2006-2007年：上海生物信息技術(shù)研究中心生命科學(xué)數(shù)據(jù)中心技術(shù)骨干
　　2003-2006年：華中科技大學(xué)生命科學(xué)與技術(shù)學(xué)院生物醫(yī)學(xué)工程專業(yè) 博士
　　2000-2003年：華中科技大學(xué)生命科學(xué)與技術(shù)學(xué)院生物醫(yī)學(xué)工程專業(yè) 碩士　　

研究方向

生物醫(yī)學(xué)大數(shù)據(jù)

研究?jī)?nèi)容

　　1. 生物醫(yī)學(xué)大數(shù)據(jù)綜合平臺(tái)
　　2. 生命科學(xué)知識(shí)庫
　　3. 精準(zhǔn)醫(yī)學(xué)知識(shí)庫
　　4. “1+2+3+X”的大數(shù)據(jù)技術(shù)體系，即以多維組學(xué)數(shù)據(jù)百科全書（NODE）、國(guó)際組學(xué)數(shù)據(jù)匯聚平臺(tái)（AntNest）、微生物基因組及元件匯交共享平臺(tái)為中心的1個(gè)生物大數(shù)據(jù)匯交匯聚體系、“精準(zhǔn)醫(yī)學(xué)多組學(xué)+微生物多組學(xué)”的2個(gè)在線分析云平臺(tái)、“表型大數(shù)據(jù)+隊(duì)列大數(shù)據(jù)+臨床科研大數(shù)據(jù)”的3個(gè)數(shù)據(jù)研究平臺(tái)，以及X個(gè)特色數(shù)據(jù)庫與知識(shí)庫。　　

代表論著（#第一作者，*通訊作者）

Wan Liu#, Pingping Wang#, Xinhao Zhuang#, Yunchao Ling, Haiyan Liu, Sheng Wang, Haihan Yu, Liangxiao Ma, Yuguo Jiang, Guoping Zhao, Xing Yan*, Zhihua Zhou*, Guoqing Zhang*. RDBSB: a database for catalytic bioparts with experimental evidence. Nucleic Acids Res 2025 Jan 6;53(D1):D709-D716.
Lei Liu, Suqi Cao, Weili Lin, Zhigang Gao, Liu Yang, Lixin Zhu, Bin Yang, Guoqing Zhang*, Ruixin Zhu*, Dingfeng Wu*. miMatch: a microbial metabolic background matching tool for mitigating host confounding in metagenomics research. Gut Microbes 2024 Jan-Dec;16(1):2434029.
Jiaxin Yang#, Xinhao Zhuang#, Zhenqi Li, Gang Xiong, Ping Xu*, Yunchao Ling*, Guoqing Zhang*. CPMKG: a condition-based knowledge graph for precision medicine. Database (Oxford) 2024 Sep 27;2024:baae102.
Wenxing Gao#, Weili Lin#, Qiang Li#, Wanning Chen, Wenjing Yin, Xinyue Zhu, Sheng Gao, Lei Liu, Wenjie Li, Dingfeng Wu, Guoqing Zhang*, Ruixin Zhu*, Na Jiao*. Identification and validation of microbial biomarkers from cross-cohort datasets using xMarkerFinder. Nat Protoc 2024 Sep;19(9):2803-2830.
Rong Zhou＃, Chen Suo＃, Yong Jiang＃, Liyun Yuan, Tiejun Zhang, Xingdong Chen*, Guoqing Zhang*. Association of Sleep Pattern and Genetic Susceptibility with Obstructive Sleep Apnea: A Prospective Analysis of the UK Biobank. Nat Sci Sleep 2024 May 23;16:503-515.
Qianqian Peng#, Xinxuan Liu#, Wenran Li#, Han Jing#, Jiarui Li, Xingjian Gao, Qi Luo, Charles E. Breeze, Siyu Pan, Qiwen Zheng, Guochao Li, Jiaqiang Qian, Liyun Yuan, Na Yuan, Na Yuan, Chenglong You, Siyuan Du, Yuanting Zheng, Ziyu Yuan, Jingze Tan, Peilin Jia, Jiucun Wang, Guoqing Zhang, Xianping Lu, Leming Shi, Shicheng Guo, Yun Liu, Ting Ni, Bo Wen, Changqing Zeng, Li Jin, Andrew E. Teschendorff*, Fan Liu*, Sijia Wang*. Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits. Nat Genet 2024 May;56(5):846-860.
Yinzhao Wang#*, Liuyang Li#, Qiang Li#, Yaoxun Hu, Wenjie Li, Zhile Wu, Hungchia Huang, Zhenbo Lv, Wan Liu, Ruifang Cao, Guoping Zhao*, Fengping Wang*, Guoqing Zhang*. MASH-Ocean 1.0: Interactive platform for investigating microbial diversity, function, and biogeography with marine metagenomic data. Imeta 2024 May 19;3(3):e201.
Lei Liu#, Liu Yang#, Suqi Cao, Zhigang Gao, Bin Yang, Guoqing Zhang*, Ruixin Zhu*, Dingfeng Wu*. CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides. Brief Bioinform 2024 Mar 27;25(3):bbae190.
Hanwen Zhou#, Liyun Yuan#, Yuanhu Ju, Yue Hu, Siqi Wang, Ruifang Cao, Zefeng Wang*, Guoqing Zhang*. IDeAS: an interactive database for dysregulated alternative splicing in cancers across Chinese and western patients. J Mol Cell Biol 2024 Apr 10;15(11):mjad074.
Tingjun Xu, Wenxing Gao, Lixin Zhu*, Wanning Chen, Chaoqun Niu, Wenjing Yin, Liangxiao Ma, Xinyue Zhu, Yunchao Ling, Sheng Gao, Lei Liu, Na Jiao, Weiming Chen, Guoqing Zhang*, Ruixin Zhu*, Dingfeng Wu*. NAFLDkb: A Knowledge Base and Platform for Drug Development against Nonalcoholic Fatty Liver Disease. J Chem Inf Model 2024 Apr 8;64(7):2817-2828.
張國(guó)慶#, 趙國(guó)屏, 李亦學(xué)*. 生物醫(yī)學(xué)大數(shù)據(jù)生產(chǎn)要素價(jià)值的實(shí)現(xiàn):從數(shù)據(jù)元素起步[J]. 生命科學(xué) 2023,35(12):1545-1552.
凌鋆超#, 曹瑞芳#, 李亦學(xué)*, 張國(guó)慶*. 多組學(xué)大數(shù)據(jù)共享平臺(tái)研究進(jìn)展[J]. 生命科學(xué) 2023,35(12):1553-1560.
Jiacheng Dai#, Xiaoxiang Xi, Zidong Liu, Weicheng Wu, Sibo Zhu, Xiaoyang Zhang, Yuwei Huang, Jiayue Meng, Liyun Yuan, Chen Suo, Jiangli Xue, Ziyu Yuan, Ming Lv, Weimin Ye, Li Jin, Guoqing Zhang*, Xingdong Chen*. Single-cell sequencing of multi-region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma. Clin Transl Med 2023 Nov;13(11):e1487.
Ruifang Cao, Yunchao Ling, Jiayue Meng, Ao Jiang, Ruijin Luo, Qinwen He, Anan Li, Yujie Chen, Zoutao Zhang, Feng Liu*, Yixue Li*, Guoqing Zhang*. SMDB: a Spatial Multimodal Data Browser. Nucleic Acids Res 2023 Jul 5;51(W1):W553-W559.
Jianing Yang#, Yingmin Cui#, Dalang Yu#, Guoqing Zhang#, Ruifang Cao#, Zhili Gu, Guangyi Dai, Xiaoxian Wu, Yunchao Ling, Chunyan Yi, Xiaoyu Sun, Bing Sun, Xin Lin, Yu Zhang, Guo-Ping Zhao*, Yixue Li*, Yi-Hsuan Pan*, Haipeng Li*. A Noncoding A-to-U Kozak Site Change Related to the High Transmissibility of Alpha, Delta, and Omicron VOCs. Mol Biol Evol 2023 Jun 1;40(6):msad142.
Yimin Wang#, Yunchao Ling#, Jiao Gong#, Xiaohan Zhao, Hanwen Zhou, Bo Xie, Haiyi Lou, Xinhao Zhuang, Li Jin, The Han100K Initiative§, Shaohua Fan*, Guoqing Zhang*, Shuhua Xu*. PGG.SV: a whole-genome-sequencing-based structural variant resource and data analysis platform. Nucleic Acids Res 2023 Jan 6;51(D1):D1109-D1116.
Ling Wang#, Wan Liu#, Jieliang Liang#, Linna Zhao, Qiang Li, Chenfen Zhou, Hui Cen, Qingbei Weng*, Guoqing Zhang*. Mining of novel secondary metabolite biosynthetic gene clusters from acid mine drainage. Sci Data 2022 Dec 9;9(1):760.
Dalang Yu#, Junwei Zhu#, Jianing Yang#, Yi-Hsuan Pan#, Hailong Mu, Ruifang Cao, Bixia Tang, Guangya Duan, Zi-Qian Hao, Long Dai, Guo-Ping Zhao, Ya-Ping Zhang, Wenming Zhao*, Guoqing Zhang*, Haipeng Li*. Global cold-chain related SARS-CoV-2 transmission identified by pandemic-scale phylogenomics. Zool Res 2022 Sep 18;43(5):871-874.
Feng Xu#, Yifan Wang#, Yunchao Ling, Chenfen Zhou, Haizhou Wang, Andrew E. Teschendorff, Yi Zhao, Haitao Zhao, Yungang He*, Guoqing Zhang*, Zhen Yang*. dbDEMC 3.0: Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms. Genomics Proteomics Bioinformatics 2022 Jun;20(3):446-454.
Yunchao Ling#, Ruifang Cao#, Jiaqiang Qian#, Jiefu Li, Haokui Zhou, Liyun Yuan, Zhen Wang, Liangxiao Ma, Guangyong Zheng, Guoping Zhao, Zefeng Wang*, Guoqing Zhang*, Yixue Li*.??An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2. Sci Bull (Beijing) 2022 Apr 15;67(7):665-669.
Yiwei Wang#, Jiaxin Yang#, Xinhao Zhuang#, Yunchao Ling, Ruifang Cao, Qingwei Xu, Peng Wang*, Ping Xu*, Guoqing Zhang*. Linking genomic and epidemiologic information to advance the study of COVID-19. Sci Data 2022 Mar 30;9(1):121.
Dalang Yu#, Xiao Yang#, Bixia Tang#, Yi-Hsuan Pan#, Jianing Yang#, Guangya Duan#, Junwei Zhu, Zi-Qian Hao, Hailong Mu, Long Dai, Wangjie Hu, Mochen Zhang, Ying Cui, Tong Jin, Cui-Ping Li, Lina Ma, Language translation team, Xiao Su, Guoqing Zhang*, Wenming Zhao*, Haipeng Li*. Coronavirus GenBrowser for monitoring the transmission and evolution of SARS-CoV-2. Brief Bioinform 2022 Mar 10;23(2):bbab583.
Ning-ning Liu, Na Jiao, Jing-Cong Tan, Ziliang Wang, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Lo Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nat Microbiol 2022 Feb;7(2):238-250.
Lu Zhang#, Ruifang Cao#, Tiantian Mao, Daqing Lv, Liangfu Yang, Yuanyuan Tang, Mengdi Zhou, Yunchao Ling, Guoqing Zhang*, Tianyi Qiu*, Zhiwei Cao*. SAS: A Platform of Spike Antigenicity for SARS-CoV-2. Front Cell Dev Biol 2021 Sep 20;9:713188.
Dingfeng Wu#, Wenxing Gao#, Xiaoyi Li#, Chuan Tian, Na Jiao, Sa Fang, Jing Xiao, Zhifeng Xu, Lixin Zhu, Guoqing Zhang*, Ruixin Zhu*. Dr AFC: drug repositioning through anti-fibrosis characteristic. Brief Bioinform 2021 May 20;22(3):bbaa115.
Weidi Huang#, Yunchao Ling#, Sirui Zhang, Qiguang Xia, Ruifang Cao, Xiaojuan Fan, Zhaoyuan Fang, Zefeng Wang*, Guoqing Zhang*. TransCirc: an interactive database for translatable circular RNAs based on multi-omics evidence. Nucleic Acids Res 2021 Jan 8;49(D1):D236-D242.
Hangyu Zhang#, Liyun Yuan#, Lulu Liu, Cong Yan, Jinming Cheng, Qihan Fu, Zhou Tong, Weiqin Jiang,Yi Zheng, Peng Zhao, Guoqing Zhang*, Weijia Fang*. Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab. BMC Cancer 2020 May 13;20(1):416.
Chenfen Zhou#, Qingwei Xu, Sheng He, Wei Ye, Ruifang Cao, Pengyu Wang, Yunchao Ling, Xing Yan, Qingzhong Wang, Guoqing Zhang*. GTDB: an integrated resource for glycosyltransferase sequences and annotations. Database (Oxford) 2020 Jan 1;2020:baaa047.
Yang Gao#, Chao Zhang#, Liyun Yuan#, YunChao Ling, Xiaoji Wang, Chang Liu,Yuwen Pan, Xiaoxi Zhang, Xixian Ma, Yuchen Wang, Yan Lu,Kai Yuan, Wei Ye,Jiaqiang Qian, Huidan Chang, Ruifang Cao, Xiao Yang, Ling Ma, Yuanhu Ju,Long Dai, Yuanyuan Tang, The Han100K Initiative§, Guoqing Zhang, Shuhua Xu*. PGG.Han: the Han Chinese genome database and analysis platform. Nucleic Acids Res 2020 Jan 8;48(D1):D971-D976.
Dalang Yu#, Lili Dong#, Fangqi Yan#, Hailong Mu#, Bixia Tang#, Xiao Yang, Tao Zeng, Qing Zhou, Feng Gao, Zhonghuang Wang, Ziqian Hao, Hongen Kang, Yi Zheng, Hongwei Huang, Yuzhang Wei, Wei Pan, Yaochen Xu, Junwei Zhu, Shilei Zhao, Ciran Wang, Pengyu Wang, Long Dai, Mushan Li, Li Lan, Yiwei Wang, Hua Chen, Yixue Li, Yunxin Fu, Zhen Shao, Yiming Bao, Fangqing Zhao, Luonan Chen, Guoqing Zhang*, Wenming Zhao*, Haipeng Li*. eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses. Natl Sci Rev 2019 Oct;6(5):867-869.
張國(guó)慶#, 寧康, 職曉陽, 劉婉, 徐萍, 周豪魁, 胡黔楠, 趙國(guó)屏*. 建設(shè)微生物組大數(shù)據(jù)中心發(fā)揮長(zhǎng)期科學(xué)影響[J]. 中國(guó)科學(xué)院院刊 2017, 032(003):280-289.
Shuang Yang#, Guoqing Zhang#, Wan Liu, Zhen Wang, Jifeng Zhang, Dongshan Yang, Y. Eugene Chen*, Hong Sun*, Yixue Li*. SysFinder: A customized platform for search, comparison and assisted design of appropriate animal models based on systematic similarity. J Genet Genomics 2017 May 20;44(5):251-258.
Guoqing Zhang*, Yunsheng Zhang, Yunchao Ling, Jia Jia. Web Resources for Pharmacogenomics. Genomics, Proteomics & Bioinformatics 2015 Feb;13(1):51-54.
Jian Chen#, Jia Sheng#, Dijing Lv, Yang Zhong, Guoqing Zhang*, Peng Nan*. The optimization of running time for a maximum common substructure-based algorithm and its application in drug design. Comput Biol Chem 2014 Feb;48:14-20.
Shen Niu#, Zhen Wang#, Dongya Ge#, Guoqing Zhang*, Yixue Li*. Prediction of functional phosphorylation sites by incorporating evolutionary information. Protein Cell 2012 Sep;3(9):675-690.
Ying He#, Menghuan Zhang#, Yuanhu Ju, Zhonghao Yu, Daqing Lv, Han Sun, Weilan Yuan, Fei He, Jianshe Zhang, Hong Li, Jing Li, Rui Wang-Sattler, Yixue Li, Guoqing Zhang*, Lu Xie*. dbDEPC 2.0: updated database of differentially expressed proteins in human cancers. Nucleic Acids Res 2012 Jan;40(Database issue):D964-D971.